ABSTRACT
This paper presents the evaluation results of the yield target setting precision of the revised MOET App (v.2.0), following the inclusion of the correction factors generated from rice biomass correlations between MOET and nutrient omission plot setups obtained from 2017 to 2018. The project started with trainings on MOET kit and MOET App use for the seed production personnel across PhilRice stations in Nueva Ecija, Negros, Bukidnon and Agusan in 2018 DS. Included in the trainings were the establishment of MOET kit tests and generation of variety- and site-specific recommendations via the MOET App for several nationally or regionally recommended varieties (NSIC Rc 122, 160, 216, 218, 222, 238, 286, 300, 358, 402, 436, 440, 442, 480, PSB Rc18 and PSB Rc82) that each PhilRice station intended to produce in the succeeding 4 cropping periods from 2019 to 2020. Relative yield advantages and economic benefits from using the MOET App fertilizer recommendations over PhilRice' current fertilizer management in seed production per station were monitored every cropping while the precision evaluation of yield target setting was done after the last cropping of 2020 WS. In 2019, relative yield advantages averaged 0.43t ha-1 in DS and 0.25t ha-1 in WS. In 2020 DS, an average relative yield advantage of 0.63t ha-1 was obtained across stations and 0.93t ha-1 in 2020 WS in Nueva Ecija only due to travel restrictions brought about by the COVID-19 pandemic. Economic benefits of using the MOET App showed an average of 0.50t ha-1 and 0.65t ha-1 yield increase over the seed production units' fertilizer management in DS and WS, respectively. While savings in fertilizer cost were better realized during the WS at an average of Php 4,126.34 ha-1 season-1 across stations. Results of the precision evaluation of the yield target showed marked improvements with a 95.24% probability of achieving 17% higher grain yields than the target set by MOET App v.2.0. However, the overall normalized Root Mean Square Error (nRMSE) of 38.14% exceeded the range for a fairly acceptable fit with the model due to large gaps between target and actual yields obtained from DS field trials.
ABSTRACT
The main food consumption of farming families is an important concern during the pandemic. Farmers in West Nusa Tenggara (WNT) survive with the availability of rice to support household health and food security during the pandemic. In addition to its nutritional content, rice also contains phenolic compounds and has antioxidant activity. This study aims are to measure the frequency of rice consumption, food variety, varieties of rice consumed daily during the pandemic in WNT, as well as the antioxidant properties of several rice varieties grown in WNT. This study was conducted from September 2020 to June 2021 in East Lombok, Sumbawa and Bima Regencies, WNT Province, Indonesia using a survey approach. The data collection techniques were observation, Focus Group Discussion, recording, interviews with 74 respondents with a semi-structured questionnaire and study literature related to the nutritional content and bioactive compound of the rice. Quantitative data was tabulated to determine the frequency and average then descriptively analyzed, while qualitative data was thematically analysed. The most consumed rice varieties are seen from the production data of seed breeders in the WNT region, the phenolic content was determined using Folin-Ciocalteu, antioxidant activity was examined using DPPH assay. The result showed that the highest portion of food consumed by farmer households in WNT is rice. The most variety of rice produced by breeders is the Inpari 32 variety. There are about 97% of farmers consume rice for 3 times a day, while 3% of the remaining consume 2 times a day of rice. Food variety includes 7.9% vegetable-rice and 92.1% rice-vegetables-meat protein. The results of the analysis of antioxidant properties and phenolic content in rice is depending on the variety. The antioxidant properties of the Jeliteng, Baroma, Pamelen, Nutrizinc and Inpari 32 rice varieties were 44.85+or-0.51%, 9.87+or-1.55%, 9.96+or-1.22%, 9.75+or-1.09%, and 14.305+or-1.24%, respectively, while the phenolic contents were 9.76+or-0.09, 4.23+or-0.03, 4.48+or-0.02, 4.64+or- 0.07, 4.58+or-0.42 mg GAE/g dryrice extract, respectively. The results of this study indicate that rice has been used as one of antioxidants source for farming families during the pandemic.
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In present manuscript describes synthesis of silver nanoparticles using turmeric leaves extract, traditional turmeric is a common spice that comes from the root of Curcuma longa, chemical called curcumin. Turmeric has a warm, bitter taste and is frequently used to flavor or color curry powders, mustards, butters, and cheeses. People commonly use turmeric for osteoarthritis, hay fever, depression, high cholesterol, liver disease, itching. There is also no good evidence to support using turmeric for COVID-19. Synthesis of silver nanoparticles AgNO powder was dissolved in distilled water to prepare 10 mM AgNO stock 3 3 solution from which different composition prepared. The AgNO solutions were mixed with urmeric plants 3 t leaves extract in equal proportion in flask. The flask was wrapped with an aluminum foil and was then heated in a water bath at 50-60 C for 2 hours. The synthesis of nanoparticles, which was confirmed by UVSpectra and TEM. UV-Vis spectra and visual observation showed that the color of the fresh leaf extractsof Vinca rosea turned into brownish yellow, respectively, after treatment with silver. In addition, TEM analysis confirmed that AgNO solutions for all concentrations produced ilver nanoparticles and their average size 3 s was less than 20 nm. Turmeric plants extract of fresh leaves can be used as bioreducing agents, drug resistant strains, toxic nature towards microbial agents, play an important role in nanoscience and nanotechnology, particularly in nanomedicine and potential applications in cancer diagnosis and therapy.
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SARS-CoV-2 genome encodes two large polyproteins (pp), pp1a and pp1ab which are cleaved and transformed into a mature form by a protease, non-structural protein 3 (NSP3). NSP3 is encoded by open reading frame (ORF) 1a/b. Curcuma longa (C. longa) or turmeric has been documented to have antiviral effects. The aim of this study was to assess the viral activities of C. longa against SARS-CoV-2 focusing on its potency to inhibit viral replication by targeting NSP3. PubChem databases were used to obtain the metabolic profile of C. longa. The compound's interaction with nucleocapsid was analyzed using molecular docking with Molegro Virtual Docker. Bioinformatics analysis based on rerank score presents all compounds of C. longa have higher binding affinity than the native ligand with cyclocurcumin as the lowest score (-128.38 kcal/mol). This anti-viral activity was hypothesized from the similarity of hydrogen bonds with amino acid residues Ser 128 and Asn 40 as key residues present in Ribavirin. This study reveals that C. longa is the potential to be developed as an antiviral agent through replication inhibition in SARS-CoV-2 targeting its replication mediated by NSP3.
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The importance of food supply throughout the world has once again shown its significance in the COVID-19 pandemic period. A continuous food supply is possible with correct agricultural programming. An effective agricultural product programming can only be possible by obtaining precise agricultural data. However, it is very difficult to gather accurate agricultural production statistics from all over the world and confirm their accuracy. In this study, the compatibility of the production statistics of six important agricultural products (wheat, rice, potato, onion, banana, apple) which had been collected from local sources, and had published as opensource by the Food and Agriculture Organization of the United Nations, with Benford's law was examined for the first time. Data for the last two decades are used to ignore the impact of annual fluctuations. The compatibility of theoretically expected and observed data was tested by Chi-square (X2) and Mean Absolute Deviation (MAD) tests. Although inconsistencies were found in some data by examining the numbers in the first, second, and first two digits, in general, the MAD test results gave a mostly concordant result.
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The study is a review of natural raw materials that can prevent infection and help treat viral infections, including those that cause COVID-19. The condition of not getting infected with pathogens that cause infections of the upper and lower respiratory tract is high the body resistance. An important element that influences the proper immunity of the body is the diet. The functioning of the immune system is improved by bee products, and plant materials: purple coneflower herb, flower and root, licorice root, aloe gel and Baikal skullcap root, as well as black cumin seed oil, chaga mushroom, lemon balm leaves and chamomile flowers. Strengthening immunity is conducive to maintaining a good mood and reducing stress. The antiviral activity has been confirmed for many plant materials, especially those containing essential oils. Natural products can be used for prevention and treatment. The country that copes best with the coronavirus epidemic is China, thanks to a combination of academic and natural medicine. The study quotes an excerpt from the "Handbook of COVID-19 Prevention and Treatment", prepared by Chinese doctors, with particular attention to the recipes used by them.
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Cold storage is expensive for smallholder farmers and seed processors in developing countries. Smallholder farmers continue to resort to traditional storage methods such as polypropylene (PP) bags for maize grain storage. They often dose the grains with chemicals to preserve them. However, hermetic bags have proven to provide superior protection to grains during storage without chemical treatment. With the advent of the COVID-19 virus which distorted many food systems across continents, stakeholders in the grain industry need to adopt better systems to reduce post-harvest food loss and improve food security. In this study, maize grain quality, nutritional content and viability were compared under three storage methods (PP bags with Phostoxin treatment, cold storage, and hermetic bag) over a storage period of four months. The results showed that the hermetic bag maintained the moisture content (MC) of the stored grains with 0.40% variations from the initial MC of 13% at the end of the storage period compared to 0.70% and 1.10% for grains stored under cold storage and in PP bags, respectively. Grain damage after the 4th month of storage in the hermetic bag had only increased by 0.40% from an initial 13.3% before storage compared to an increase of 6% for cold storage, which was attributed to unstable power during the storage period, and 4.30% for grains stored in the PP bag. Carbon dioxide concentration in the hermetic bag was maintained at about 11% throughout the storage period indicating low microbial activity. The hermetic bag technology was identified as the best option for quality preservation during storage of maize grain over the other methods, and its adoption by smallholder farmers in Ghana should be considered.
ABSTRACT
Increasing body immunity is very necessary after the Covid-19 pandemic. One of the efforts that can be made to increase the body's immunity is to consume functional foods with immunostimulant activity, such as processed snakehead fish products in the form of nuggets, and "parkusel" juice made from a mixture of bitter melon, dates and celery. The purpose of community service is to provide knowledge and skills to housewives and the community at the Veteran ABRI Housing Complex in Medan Estate, Deli Serdang Regency, in making functional food products in the form of snakehead fish nuggets and Perkusel juice. The community service method used is the counseling method with leafet aids and training in making snakehead fish nuggets and perkusel juice. The results of the activity showed that there was an increase in the knowledge of the community participants in community service activities about nutritious snack products that can increase body immunity by 71% in the good value category.
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Coronavirus was detected in Bangladesh first time on March 8, 2020 officially. But Coronavirus Disease (COVID-19), first reported in December 2019 from Wuhan in China, had reached the stage of a pandemic. This study was conducted to know the effects of spices against Covid-19 disease, impact of Covid-19 on agro-economy of spices crop and point out of mitigating of spices problem in Bangladesh. Major production of spices was severely affected, causing raw material shortages to the spice production of Bangladesh. Major for spices crop problem were shortages caused by the migration of the workforce due to lockdown. Continuing operation on the industry floor, in the midst of social distancing, and ensuring safety of the spices production, was also a major issue. Although the entire sectors were hit by the economic disruptions, the small-scale spice producers and processors most severely affected. The novel coronavirus disease (COVID-19) pandemic and the prolonged lockdown have made thousands of farmers, labours and traders feel the pinch of a falling spices yield and sale. Increased production cost of onion, chilli, garlic, ginger, turmeric, coriander and black cumin due to Covid-19 situation over normal situation were 10.33, 9.54, 9.04, 11.46, 9.58, 6.21 and 7.21%, respectively. Market price of onion, chilli, garlic, ginger, turmeric, coriander and black cumin were also increased 5.00, 3.90, 1.39, 3.13, 1.40, 1.25 and 2.67 times, respectively, due to the influence of Covid-19.
ABSTRACT
The production of wheat, as one of the elementary and strategic nutrition crops, in North Macedonia is insufficient and cannot meet the national demands, which results with negative trade balance with import of 74,937 tons of wheat valued at 17.9 million EUR. The main goal of this paper is to analyse the influence of international markets on wheat prices in the Republic of North Macedonia. Data on the purchase price of wheat have been analysed using statistical methods and models from December 2009 to December 2021. A total of 145 monthly time series with data on the purchase price of wheat for Macedonia, the EU, Bulgaria, Romania and Serbia have been analysed and compared. The Pearson correlation coefficient shows a relatively high relationship and mutual dependence of purchase prices in Macedonia, compared to prices in the EU, Bulgaria, Romania and Serbia (over 65%). The purchase prices of wheat in Macedonia have the highest relationship and mutual dependence with the price movement in Serbia (0.78), and the lowest with the price movement in the EU (0.66). The estimated lag length of the autoregressive process (AIC, BIC, FPE and HQIC tests), on average shows 2 lags (months) later time reaction of the wheat prices in Macedonia with the comparison countries countries. The forecasting model (Granger causality test) shows that time series of wheat prices can be convenient for forecasting wheat prices in Macedonia. As of October 2021, the model clearly shows the impact of food economic crisis and unexpected, immediate rise of wheat prices as result of the post Covid-19 and Ukraine war crisis. This research and analysis model can provide significant information for the wheat price trends, forecasting and markets shock, as management and decision-making tools for producers, traders and processors, but also for the policy makers.
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The consumption of spices is growing in India with an increase in purchasing power. It is forecasted that everyone in the country would be consuming one spice or the other with a high per capita consumption. It is estimated that we may have a population of around 1.69 billion people during 2050 and approximately the per capita consumption of turmeric, ginger, black pepper and cardamom is expected to be about 1.6 kg, 1.2 kg, 148 g and 54 g, respectively. This may increase further owing to rapid urbanization which needs spices as natural food preservatives. Hence, the present study was conducted to analyze the growth trend in spices economy of India during the period 1990-91 to 2021-22 with reference to the selected growth indicators such as area, production, domestic market, export and export value. For estimating the acceleration in the growth rates, the paper uses semi-logarithmic specification of a non-linear (quadratic) equation. From the analysis, it is observed that there is a huge scope for output and export of spices. Despite the Covid pandemic, spices export from India has continued its upward trend during 2020-21 and has attained an all-time high of US $ 4.0 billion mark for the first time in the history of spices export. It also implies that there is strong domestic market for spices in India.
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As the world was emerging from the Covid-19 pandemic earlier this year, it was thrown off course by the Russian invasion of Ukraine. Geopolitical instability and conflicts now remain a top concern as the greatest risk to global growth over the next 12 months. Production costs are rising. We are in a totally new world, and companies are going to have to reconfigure how they think about their operations. Against this backdrop, the global sugar industry, invariably sucked in the vortex of the storm will have to manage. Sugar prices are holding up, moderated as much by climate volatility dictating uncertainty and macroeconomic indicators, in particular the value of US$. Global sugar production in 2022/23 (Oct/Sep) is forecast at 191.1 million tonnes raw value (mtrv) while the consumption is expected to rise by 0.9% to 186.8 million tonnes suggesting a global surplus following the deficit of 2.2 mtrv in the previous year. Sugar production in the top-producing countries Brazil, India and Thailand will sway the market as will the top consumers Indonesia and China.
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Introduction and objective:The latest scientific reports showed that there is a relationship between the state of the gastrointestinal tract and the immune system, and the incidence of COVID-19. Diet can exert an immunomodulatory effect and regulate the immune response of an organism. The aim of the review is to show the effects of immunomodulators contained/supplemented in a diet on the infection SARS-CoV-2 and the course of COVID-19. Review methods:The literature review was conducted using PubMed, Google Scholar and the Medline database. Abbreviated description of the state of knowledge:Regular vitamin D supplementation significantly reduces the risk of respiratory infection with SARS-CoV-2;vitamin C may inhibit the expression of the ACE2 receptor in human small alveolar epithelial cells and limit the penetration of SARS-CoV-2;reduced iron levels predispose people to severe COVID-19 symptoms;selenium deficiency may be responsible for a decreased level of antibodies and NK cell cytotoxicity. Alo.. vera isolated polysaccharides strengthens the immune system;the quercetin and ellagic acid in combination with virus proteins show potential antiviral activity against SARSCoV- 2. Subsequently, adaptogens, ginger, echinacea and curcumin - showed anti-inflammatory effects. Also, the optimal composition of the gut microbiota improved/maintained the integrity of the lymphoid tissue found in the gastrointestinal tract (GALT) and the functioning of the gut-pulmonary axis. Summary:Natural immunomodulators may be a relatively safe therapeutic option in patients during the course of COVID-19, but there are still no official recommendations for their practical use in therapy. It should be emphasized that there is a need for further scientific research into the mechanisms of action and efficacy of phytotherapy in the context of the effectiveness of plant-based immunostimulants in alleviating the course of COVID-19 disease.
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This study aims to analyze the AntiCovid effect of Phytocompounds extracted from Native Indian Plant species by computational methods such as Molecular Docking. Through this study keeping the Indian Heritage alive we characterized the ability of these phytochemicals as inhibiting agents of the Main Protease enzyme of this Virus. The lack of any effective treatment and the reoccurrence of cases despite Vaccination necessitates the quick provision of anti-SARS-CoV-2 drugs. Natural substances are getting a lot of attention for SARS-CoV-2 therapy as they have proven antimicrobial activities and are a key source for numerous antiviral drugs. Despite the fact that this virus has several identified target receptors, Main Protease (Mpro) is crucial for viral replication. In this study, 26 phytochemicals from 10 native Indian plant species were studied. Our docking studies demonstrated that compounds Quercetin, Withaferin A, Sominone, and Nimbin were likely to be more favorable than the natural inhibitor N3, with binding energies of-8.42, -9.21, -9.95, and -8.88 kcal/mol, respectively. These four candidate natural compounds were further examined for their bioavailability scores through ADMET analysis to prove the safety of these compounds as well as their drug likeliness. Through the results it was indicated that these natural phytochemicals have a significant potential of inhibiting the SARS-CoV-2 Mpro enzyme and might be utilized to treat SARS-CoV-2 and manage public health, subject to in vitro validation in the future.
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The production of high-quality seeds and planting material is the basis for increasing the efficiency and sustainability of crop production. The main aim of this article is to develop proposals to ensure that supply meets the demand in the seed and planting material market Ukraine. The future prospects are also discussed. The paper uses statistical and comparative analysis. The patterns of foreign trade in seeds and planting material to and from Ukraine are analyzed. The high level of import dependence of Ukraine leads to excessive exposure to instability in the world seed market. The development of seed production in Ukraine is discussed and analyzed along with the ways for improving commercial circulation of seeds and planting materials. The export volumes of grains and oilseeds in 2020 were the highest of those over the last three decades and amounted to USD 18.7 million, which is almost twice more than in 2019. Corn seeds dominate in exports (72%). The volume of imports of seeds of grains and oilseeds exceeded exports by 22 times in value and, in 2020, amounted to USD 409.4 million. In the total volume of imports, imports of sunflower seeds accounted for 53%. The upward trend of seed imports has been maintained since 2010. It was the result of increased demand for imported seeds by large- and medium-sized agricultural producers. In 2020, COVID-19 gave impetus to the development of domestic seed production and foreign breeding companies within the country. Prospective ways to accelerate the development of the organization of the Ukrainian seed and planting material market are outlined. Ukraine has prospects for increasing the export of seeds of grains and oilseeds by expanding its production by foreign companies operating in Ukraine. Solving problems of competitiveness seed production in Ukraine will make it possible to strengthen the role of domestic breeding in the seed market, as well as to use the best foreign varieties through their commercial circulation.
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This study presents the anti-COVID potential of bioactive compounds from Chrysopogon zizanioides thorough in-silico molecular docking approach using AutoDock Vina software. As of our knowledge, the antiviral potential of all its bioactive compounds and their synergistic potentials against SARS-CoV-2 main-protease is not reported earlier. The results were promising with beta-Sitosterol (G = -7.5 kcal/mol;Ki = 3.13 micro M);Campesterol (G = -7.4 kcal/mol;Ki = 3.71 micro M);Stigmast-4-en-3-one (G = -7.3 kcal/mol;Ki = 4.39 micro M) forming non-covalent interactions with the amino acids in the active site of Mpro causing inhibition. The synergistic potential of compounds showed a significant sign of inhibition against Mpro with -7.9 kcal/mol with the sequential combination of beta-Sitosterol;Campesterol;Stigmast-4-en-3-one. The docking protocol validation was performed by re-docking and superimposing co-crystallized ligand, and interactions visualized using Discovery Studio 2020. Moreover, all the compounds satisfied Lipinski's oral drug-likeliness properties to be used and oral drug. These bioactive compounds of Chrysopogon zizanioides showed low binding energies against SARS-CoV-2 Mpro which proved their anti-COVID potential. Thus, by incorporating Chrysopogon zizanioides for consumption in daily life, it is very likely that one can get rid of COVID-19.
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The pattern of sugar cane trading that occurred during the COVID-19 pandemic has created a new pattern of sugar cane trading in Indonesia. This study aims to determine the pattern of the trading system undertaken by sugarcane farmers, to reveal the role of social capital in shaping the sugarcane trade system during the pandemic. This research is a qualitative research that uses primary data from interviews with key informants by multistage sampling technique. The data processing includes data reduction, data display using Decision Explorer version 3.3 software. Data were analyzed through descriptive methods and content analysis. The study found that the COVID-19 pandemic formed a new pattern of sugarcane trading system, switching from a contractual trade model to a free market model (redeemer). The model refutes the theory stating that the contractual model will be more efficient than the free market model due to its lower transaction costs. The proposition (substantive theory) produced in this study states that in conditions of sugarcane commodities facing a captive market, the market mechanism is more efficient than the contractual mechanism. Furthermore, this study found that the development of accelerative information technology during the COVID-19 pandemic (social media) has destroyed social capital between sugarcane farmers and partners (sugar factories) due to cheaper information costs borne by sugarcane farmers.
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Background: Antiviral vaccine is not effective, synthetic antiviral drugs are highly toxic, leading to increased interest in herbal medicines as promising antiviral drugs. Recently, Vipdervir has been developed from medicinal herbs with the aim to support and treat diseases caused by viruses such as H5N1 and SARSCoV- 2. In the present study, we assessed Vipdervir's antiviral activity against H5N1 and SARS-CoV-2. In addition, we also evaluated the acute toxicity and repeated dose toxicity of Vipdervir in mice and rabbits, respectively. Methods: H5N1 inhibitory effect of Vipdervir was assessed using hemagglutination inhibition assay. Vipdervir's SARS-CoV-2 inhibitory effect was evaluated by Plaque Reduction Neutralization assay. Acute and repeated dose oral toxicities of Vipdervir were determined according to OECD 423 and OECD 407 guidelines, respectively. Results: Data show that Vipdervir is effective against both H5N1 and SARSCoV- 2. At concentrations of 3 mg/mL and 5 mg/mL Vipdervir completely inhibits H5N1. At a concentration of 50 g/mL Vipdervir showed an inhibitory effect on SARS-CoV-2. Acute toxicity data revealed that the LD50 of Vipdervir is greater than 35200 mg/kg, b.wt. in mice. Repeated toxicity data indicated that Vipdervir did not induce significant differences in body weight gain, hematology and clinical biochemistry in compared to the control group. The No Observed Adverse Effect Level of Vipdervir is greater than 613.8 mg/kg b.wt./day in rabbits. No delayed toxicity effects of Vipdervir were observed. Conclusion: Vipdervir capsules were found to be antiviral effective and relatively safe in the tested doses and experimental conditions.
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This paper characterises South African sugarcane production for the 2021/22 milling season, from an agricultural perspective, to enable the industry to evaluate recent production strategies, and to identify priorities for improved efficiency. The industry's cane and sugar production during the 2021/22 season was 17.2 and 1.84 million tons, respectively. These figures show a marked drop of 5.6% for cane and 8.7% for sugar, when compared to the production figures for the 2020/21 season. The estimated industry average cane yield and quality also decreased slightly, compared to the previous season, but the main reason the drop in cane and sugar production was the limited milling capacity at several mills in KwaZulu-Natal. The civil unrest in July 2021 exacerbated the situation, causing disruptions to harvest and mill operations, as well as the subsequent closure of mills in parts of KwaZulu-Natal. The area harvested decreased considerably from an estimated 254 028 ha in 2020/21 to 241 030 ha in 2021/22 while estimated carry-over cane area increased from 24 029 ha to 32 476 ha over the same period. Rainfall was generally well above the long-term mean and well-distributed in most areas, while irrigation water supply also improved remarkably, compared to 2020 supply. Low temperatures and reduced sunshine duration caused yield reduction in the northern irrigated areas, but most rainfed areas experienced yield improvements when compared to 2020/21, because of the good rainfall. The Midlands region experienced severe frost damage during the winter of 2021, which had a negative impact on cane yield and quality. The Sugar Industry Value Chain Master Plan continued to help stabilise local sugar demand as well as reduce imports and exports at low world market prices, which all contributed to a 6% increase in the Recoverable Value (RV) price. This improved profitability for both largeand small-scale growers. COVID-19 had no noteworthy impact on sugarcane production.
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The molecular structure of hydroxychloroquine (HCQ) used in the treatment of malaria is recently suggested for emergency used in COVID-19. The chemical compound of HCQ is produced by chemical alteration of ethylene oxide from human products, such as waxy maize starch. The molecular graph is a graph comprising of atoms called vertices and the chemical bond between molecules is called edges. A topological index is a numerical representation of a chemical structure which correlates certain physico-chemical characteristics of underlying chemical compounds besides its numerical representation. To distinguish the creation of entropy-based measures from the structure of chemical graphs, several graph properties have been utilized. For computing the structural information of chemical graphs, the graph entropies have become the information-theoretic quantities. The graph entropy measure has attracted the research community due to its potential application in discrete mathematics, biology, and chemistry. In this paper, our contribution is to explore graph entropies for molecular structure of HCQ based on novel information function, which is the number of different degree vertices along with the number of edges between various degree vertices. More precisely, we have explored the degree-based topological characteristics of hydroxyethyl starch conjugated with hydroxychloroquine (HCQ-HEC). Also, we computed entropies of this structure by making a relation of degree-based topological indices with the help of information function. Moreover, we presented the numerical and graphical comparison of the computed results.